Table of Contents What Is the SASP? What Does the SASP Actually Do? The SASP and Ageing: How Chronic Inflammation Accumulates The SASP and Disease Risk Can the SASP Be Targeted Therapeutically? References and Resources Frequently Asked Questions Conclusion What Is the SASP? TL;DR: The SASP (Senescence-Associated Secretory Phenotype) is the inflammatory signalling environment produced…
Table of Contents Why Senescent Cells Accumulate With Age What Triggers Cellular Senescence? Why Clearance Fails Over Time Factors That Accelerate Accumulation Practical Implications: Can You Slow the Build-Up? References and Resources Frequently Asked Questions TL;DR: Senescent cells accumulate with age because damage-triggered senescence outpaces the body’s ability to clear these cells. Immune decline, chronic…
Table of Contents What Causes Cellular Senescence? DNA Damage: The Primary Trigger Oxidative Stress and Reactive Oxygen Species Telomere Shortening and Replicative Senescence Chronic Inflammation and Environmental Triggers Stress-Activated Signalling Pathways Practical Implications References and Resources Frequently Asked Questions Conclusion What Causes Cellular Senescence? TL;DR: Cellular senescence is primarily triggered by DNA damage, oxidative stress,…
Table of Contents What Is Cystatin C? Is Cystatin C a Reliable Marker for Kidney Function? How Is Cystatin C Measured and Interpreted? Cystatin C vs Creatinine: How Do They Compare? Practical Implications for Longevity and Health Monitoring References and Resources TL;DR: Cystatin C is a blood protein used to estimate kidney filtration rate. It…
Table of Contents Can You Lower Lipoprotein(a) Naturally? What Is Lipoprotein(a) and Why Is It Hard to Change? What the Evidence Says About Natural Approaches Lifestyle Strategies That Support Cardiovascular Health Diet and Supplements: What May Help Practical Implications: What Should You Actually Do? References and Resources Frequently Asked Questions Conclusion Can You Lower Lipoprotein(a)…
Table of Contents What Is Lipoprotein(a) and Why Does It Matter? Does High Lipoprotein(a) Increase Mortality Risk? How Lp(a) Drives Cardiovascular Risk Managing Risk When Lp(a) Is Elevated References and Resources Frequently Asked Questions Conclusion Does High Lipoprotein(a) Increase Mortality Risk? TL;DR: Yes — elevated Lipoprotein(a) is associated with significantly higher risk of cardiovascular events…
Table of Contents What Is Lipoprotein(a)? Is Lipoprotein(a) a Risk Factor for Heart Disease? How Is Lipoprotein(a) Measured? Is Lipoprotein(a) Genetic or Modifiable? Managing High Lipoprotein(a) References and Resources Frequently Asked Questions TL;DR: Lipoprotein(a) — written as Lp(a) — is a genetically determined particle that raises cardiovascular risk independently of LDL cholesterol. Because lifestyle changes…
Table of Contents What Is Taurine and How Does It Relate to Mitochondria? How Taurine Influences Mitochondrial Function What the Scientific Evidence Shows Practical Implications: Dosage and Timing Limitations and What Remains Uncertain Frequently Asked Questions References and Resources TL;DR: Taurine supports mitochondrial function primarily by reducing oxidative stress, stabilising mitochondrial membranes, and helping regulate…
Table of Contents What Is Alpha-Ketoglutarate? How AKG Works: Key Biological Mechanisms Scientific Evidence: Animal Studies Human Evidence: What Do We Actually Know? Practical Considerations and Safety Does Alpha-Ketoglutarate Extend Lifespan? A Balanced View References and Resources Frequently Asked Questions Conclusion TL;DR: Alpha-ketoglutarate (AKG) has extended lifespan in animal models and shows plausible mechanisms relevant…
Table of Contents What Is Urolithin A and What Does It Do? How Urolithin A Supports Mitochondrial Health What the Scientific Evidence Says Practical Considerations: Diet, Supplementation, and Timing Benefits, Limitations, and Uncertainty Conclusion References and Resources Does Urolithin A Improve Mitochondrial Health? TL;DR: Urolithin A is a gut-derived compound that activates mitophagy — the…