Table of Contents What Are Senolytics? How Do Senolytics Work? Natural vs Synthetic Senolytics What Does the Evidence Say? Safety, Limitations, and Practical Implications Resources and Further Reading References and Resources What Are Senolytics? TL;DR: Senolytics are compounds — both natural and pharmaceutical — that selectively eliminate senescent (“zombie”) cells from the body. In animal…
Table of Contents What Causes Cellular Senescence? DNA Damage: The Primary Trigger Oxidative Stress and Reactive Oxygen Species Telomere Shortening and Replicative Senescence Chronic Inflammation and Environmental Triggers Stress-Activated Signalling Pathways Practical Implications References and Resources Frequently Asked Questions Conclusion What Causes Cellular Senescence? TL;DR: Cellular senescence is primarily triggered by DNA damage, oxidative stress,…
Table of Contents What Is Urolithin A and What Does It Do? How Urolithin A Supports Mitochondrial Health What the Scientific Evidence Says Practical Considerations: Diet, Supplementation, and Timing Benefits, Limitations, and Uncertainty Conclusion References and Resources Does Urolithin A Improve Mitochondrial Health? TL;DR: Urolithin A is a gut-derived compound that activates mitophagy — the…
Does PQQ Improve Mitochondrial Function? TL;DR: PQQ (pyrroloquinoline quinone) has shown the ability to stimulate mitochondrial biogenesis and reduce oxidative stress in cell and animal studies, but robust human evidence remains limited. It shows promise as a mitochondrial support supplement, though it should not be viewed as a substitute for exercise and metabolic health as…
Table of Contents What Mitochondria Do and Why They Decline With Age Do Supplements Actually Improve Mitochondrial Function? The Best Supplements for Mitochondrial Support Combining Supplements With Lifestyle for Best Results References and Resources Frequently Asked Questions Conclusion TL;DR: The most evidence-supported supplements for mitochondrial function include CoQ10 (ubiquinol), NAD+ precursors (NR and NMN), PQQ,…
Table of Contents What Are the Top 5 Longevity Interventions? 1. Exercise and Physical Activity 2. Sleep Quality and Stress Management 3. Diet and Nutritional Strategy 4. Caloric Restriction and Fasting 5. Targeted Supplements and Hormetic Stressors What About Emerging Therapies? References and Resources Frequently Asked Questions Conclusion What Are the Top 5 Longevity Interventions?…
Table of Contents Drug-Based vs Lifestyle-Based Longevity: The Core Question What Lifestyle-Based Longevity Actually Delivers What Drug-Based Longevity Can and Cannot Do How Drugs and Lifestyle Compare Directly A Sensible Hierarchy: Foundations First References and Resources Frequently Asked Questions Conclusion Is Drug-Based Longevity Better Than Lifestyle-Based Longevity? TL;DR: Lifestyle changes — exercise, nutrition, sleep, and…
Table of Contents What Is Testosterone Replacement Therapy? Long-Term Safety: What the Evidence Shows Cardiovascular Risk and TRT Prostate Health and TRT TRT for Deficiency vs. Enhancement in Healthy Men Monitoring and Medical Oversight Lifestyle, Foundations, and TRT References Is Testosterone Replacement Therapy Safe Long-Term? TL;DR: Testosterone replacement therapy (TRT) can be safe long-term for…
Table of Contents Does Growth Hormone Extend Lifespan? What Growth Hormone Does in the Body What the Research Actually Shows Why Growth Hormone Is Problematic as a Longevity Intervention Risks and Benefits: An Honest Assessment Frequently Asked Questions References and Resources Does Growth Hormone Extend Lifespan? TL;DR: Current evidence does not support the use of…
Table of Contents What Are GLP-1 Medications and Why Do They Matter for Longevity? How GLP-1 Medications May Influence Ageing What the Evidence Actually Shows Cardiometabolic Risk Reduction: The Most Relevant Longevity Benefit Limitations and What Remains Unknown References and Resources Does GLP-1 Medication Improve Longevity? TL;DR: GLP-1 receptor agonists are not proven longevity drugs,…